Pharmaceuticals: Residual Impurity Analysis
FT-MRR spectroscopy is a novel technique for fast genotoxic impurity and residual solvent analysis. The BrightSpec FT-MRR impurity analyzer can monitor a broad range of compounds with the particular subset chosen and modified by the user. Both static headspace methods at the bench-top and direct analysis of vapors in drying chambers are compatible with FT-MRR instruments. Once the solution headspace or off-gassing vapors are introduced into the spectrometer measurement cell, each analyte of interest can be detected quantitatively in seconds. Since genotoxic impurity and residual solvent are critical quality metrics in pharmaceutical process research and development, it makes sense to get both answers at once. FT-MRR spectroscopy can be used to determine both at the same time.
BrightSpec is developing a product and services portfolio that uses a single measurement technique—Fourier transform molecular rotational resonance (FT-MRR) spectroscopy—to perform three essential chemical analysis measurements:
- Quantitative analysis of diastereomers produced in the synthesis of molecules with multiple chiral centers.
- Quantitative enantiomeric excess measurements for chiral molecules.
- Determination of the three-dimensional structure of a chiral molecule.
Currently, each of these analyses requires different measurement technologies that are expensive, time consuming, and require highly trained technical staff. In order to meet the needs of our target markets, BrightSpec is developing instruments that can perform this analysis on molecules for applications in pharmaceutical drug discovery.
Government & Academic: Fundamental Research
Molecular rotational spectroscopy is a high-resolution, direct gas mixture analysis technique that has become an important tool for studying radicals, reaction intermediates, and weakly bound complexes. The direct connection of the MRR spectral signature to molecular structure gives scientists an accurate view of the molecule itself. FT-MRR is the fastest and most sensitive way to do it, and speed can make all of the difference when analyzing composition of low abundance species in conditions that are difficult to reproduce. For investigative analyses, where the matrix is unknown, BrightSpec broadband spectrometers give researchers a wide view of the spectrum and advanced analytical tools to speed discovery in both millimeter-wave and microwave regions of the spectrum.
Industrial Gas: Gaseous Impurities
FT-MRR brings a unique capability for trace gas detection—user selectable, multi-species detection in one instrument. By other techniques, many of the light-weight gases that are important to monitor are either unresolvable in complex mixtures or too unstable to detect without derivatization. FT-MRR instruments can monitor species like methanol, formaldehyde, ethylene oxide, and hydrogen cyanide to trace levels (< 1ppm) without chromatography. The gas mixture is measured in its integrity by siphoning off μL amounts which can then be cycled back into the feed gas. The molecular structure specificity and high selectivity of FT-MRR combine to form a powerful, yet simple solution for gas mixture analysis.
Environmental: Air and Water
The strength of FT-MRR lies in small molecule volatiles analysis where interference issues create a challenge for GC techniques and force customization of the analysis. The list of toxic volatiles that can be monitored directly all in the same FT-MRR instrument is extensive. One of the most unique features of the FT-MRR spectral signature is the direct connection to molecular mass distribution. Molecular isotopologues can be distinguished from each other, and with a dynamic range of 106, FT-MRR can view them in natural abundance.