Beyond Mass: Structure-Specific Quantitation of Closely Related Impurities in Pharmaceutical Raw Materials
Summary
Finding impurities in pharmaceutical raw materials can often feel like finding a needle in a haystack. Many impurities are regioisomers, meaning they share the same formula and weight as the intended compound. As a result, traditional analytical techniques can struggle to identify them accurately. This presents a challenge for quality teams as they need to ensure that unwanted chemicals do not carry through to intermediates or final drug substances.
Molecular rotational resonance (MRR) spectroscopy offers an alternative approach for detecting and quantifying regioisomers based on their unique rotational spectra. The technique collapses hours of method development into a single workflow while eliminating the need for chromatography.
Download the application noteto learn how MRR identified and quantified four structurally similar pharmaceutical impurities in a commercial lot of 1,2,4-trifluorobenzene using two complementary MRR workflows.
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