APPLICATION NOTE

Direct Quantitation of Ethylene Glycol in a mAb Formulation Matrix by MRR

Summary

Ethylene glycol (EG) contamination remains an important pharmaceutical safety concern, particularly as testing expands beyond raw materials to finished drug products. Analyzing EG in biologic formulations can be challenging due to the presence of buffers, salts, and excipients that may complicate traditional analytical methods.

Molecular rotational resonance (MRR) spectroscopy identifies compounds through their structure-specific rotational spectra, providing molecular specificity without relying on chromatographic separation. This enables direct EG identification and quantitation in complex formulation matrices using a streamlined workflow.

Download the application note to learn how MRR enables direct identification and quantitation of ethylene glycol in a representative mAb formulation matrix without extraction, dilution, or derivatization.