APPLICATION NOTE

Single-Method Quantitation of Chemically Diverse Residual Solvents by Molecular Rotational Resonance: Application to Peppermint Oil

Summary

Residual solvent analysis in essential oils can be challenging due to the high concentrations of volatile components and the wide range of solvent volatilities and polarities that must be measured.

Traditional methods often require multiple standard mixtures and analytical runs to accurately quantify chemically diverse solvents, while higher-boiling polar compounds can be difficult to analyze using conventional headspace techniques.

Molecular rotational resonance (MRR) spectroscopy provides a simpler, more direct approach.  By identifying compounds through their unique rotational spectra, MRR enables solvent-specific detection and quantitation without relying on baseline chromatographic resolution or retention time matching.

Download the application note to learn how MRR uses a single direct-injection method to quantify four residual solvents in peppermint oil.