POSTER

Direct Headspace-MRR Quantitation of Ethylene Glycol and Diethylene Glycol Contaminants in Glycerin

Summary

DEG and EG contamination of glycerin has caused repeated mass poisoning events, prompting FDA guidance calling for independent, container-by-container testing of high-risk excipients rather than reliance on certificates of analysis.

GC-MS is the regulatory standard for ppm-level screening, but glycerin's high viscosity requires dilution and filtration before injection, introducing variability that limits throughput in high-volume testing.

Download the poster to see how headspace molecular rotational resonance (MRR):

• Identifies compounds through their unique rotational fingerprints

• Enables unambiguous detection with minimal sample preparation and analysis times under 10 minutes.

• Offers a streamlined alternative to GC-MS for injection-challenging matrices.