Direct Quantitation of Regioisomers

MRR enables rapid identification and quantitation of challenging impurities during pharmaceutical development.

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Regioisomer Quantitation

Even though regioisomers (also known as ‘positional isomers’) have the same molecular formula, their specific functional groups are located at different positions within a parent molecular structure or chain. This difference in molecular geometry may significantly impact both efficiency and safety of a drug product. Therefore, identification and quantitation of regioisomer impurities is a very important task for pharmaceutical industry at essentially all stages of drug discovery and production: from raw materials and intermediates to drug candidates and final drug products.

Yet, this task poses serious challenges for conventional analytical techniques including chromatography and mass spectrometry (MS). 

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