A Novel Method for Measuring Site-Specific Deuteration
Deuteration has long held the promise of improving drug stability and reducing toxicity, among other
benefits. Until now, a general method to install deuterium into a small molecule in a highly selective
manner was unavailable. In the Journal of the American Chemical Society article, Prof. Clark details
novel chemistry that allows for site-specific deuteration to access deuterated small molecules with
high levels of isotopic purity.
