Streamline Complex Residual Solvent Analysis

Achieve identity and quantitation data in one simple measurement.

Read the App Note

What You'll Learn

  • No Chromatography Needed

    How to identify and quantify volatile residuals without the need for gas chromatography or complex method development.

  • Versatile Sample Compatibility

    Why MRR works effectively with challenging solvents, including high-boiling point and water-soluble acids.

  • Key Advantages over Traditional Methods

    How BrightSpec's MRR platform compares to conventional techniques in terms of speed, simplicity, and accuracy.

Problem and Solution

Problem

Analyzing volatile residuals often requires extensive method development, especially when dealing with problematic solvents. Traditional chromatography methods can be time-consuming and may struggle with certain solvent classes, leading to prolonged development timelines and potential inaccuracies.

Solution

BrightSpec's MRR technology offers a novel approach by providing identity and quantitation data in a single measurement. This eliminates the need for complex method development, allowing for rapid and accurate analysis of volatile residuals, even those that are challenging for traditional methods

Faster Analysis Workflows

MRR Analysis Speed

3x

Traditional GC methods

The simplified workflow results in a dramatic reduction in time achieved using headspace-MRR compared to traditional GC workflows. MRR can save you 40 to 70 minutes per sample.

Strong, Clear Signal

Screenshot 2025-05-13 112453

 

 

 

 

 

 

 

 

Figure 4 from the app note demonstrates an MRR Signal response and quantitative performance for formaldehyde in aqueous solution.

Featured Recently

2-Apr-15-2025-04-08-47-2383-PM

This article demonstrates that MRR with continuous headspace sampling is capable of not only accelerating the analysis of residual solvents via direct analysis but also bridging the analytical gap of SH-GC for analysis of low-volatile residual solvents from USP Residual Solvents Class 2 — Mixture C RS.

Read here

 

 

USP Stimuli

"Direct Analysis of Class 2 Residual Solvents Using Molecular Rotational Resonance Spectroscopy"

Video Overview

Resources

Article

USP Stimuli: MRR for Class 2 Residual Solvent Analysis

Read how MRR met USP and ICH selectivity, sensitivity, linearity, and range requirements for all solvents studied, including solvents poorly suited for GC analysis.

Learn More

App Note

Formaldehyde Quantitation

Learn how MRR simplifies formaldehyde quantitation with no derivatization and no separation.

Learn More

Brochure

Meet the isoMRR

Streamlined analysis, precise quantification, and chiral clarity—all in one powerful platform.

Learn More

Article

USP Stimuli: MRR for Class 2 Residual Solvent Analysis

Read how MRR met USP and ICH selectivity, sensitivity, linearity, and range requirements for all solvents studied, including solvents poorly suited for GC analysis.

Learn More

App Note

Formaldehyde Quantitation

Learn how MRR simplifies formaldehyde quantitation with no derivatization and no separation.

Learn More

Brochure

Meet the isoMRR

Streamlined analysis, precise quantification, and chiral clarity—all in one powerful platform.

Learn More