Differentiate Regioisomers & Related Impurities with Confidence 

This application note demonstrates how molecular rotational resonance (MRR) spectroscopy enables structure-specific identification and quantitation of closely related impurities in pharmaceutical raw materials. Using regioisomers and structural analogs in commercial 1,2,4-trifluorobenzene as an example, MRR differentiates compounds that share similar molecular formulas and properties while achieving low-ppm impurity detection and quantitation.

Application Note Highlights

• Learn how MRR differentiates regioisomers and structurally related impurities that mass alone cannot distinguish.

• Explore complementary headspace-MRR and PTV-MRR workflows for impurity analysis.

• See how MRR quantifies low-level impurities in commercial 1,2,4-trifluorobenzene with strong linearity and repeatability.

• Understand how structure-specific analysis supports impurity assessment in pharmaceutical building blocks and reagents.

Download the application note to learn more.