Direct Residual Solvent Identification & Quantitation 

This scientific poster demonstrates how molecular rotational resonance (MRR) spectroscopy enables high-throughput, fully automated analysis of USP <467> residual solvents using a headspace workflow. By combining structure-specific molecular identification with targeted quantitation, headspace-MRR provides reliable residual-solvent analysis without chromatographic separation while extending analytical coverage beyond conventional headspace gas chromatography (GC) methods.

Poster Highlights

• Demonstrates fully automated headspace-MRR analysis of USP <467> residual solvents.

• Enables direct molecular identification without chromatographic separation.

• Provides reliable quantitation in mixtures without spectral overlap.

• Expands analytical coverage to low-volatility compounds, acids, and amines.

• Validates quantitative performance against USP <467> criteria for representative residual solvents.

• Supports high-throughput analysis with automated workflows and approximately 30-minute sample cycle times.

Download the scientific poster to learn more.