Accelerate Chiral Raw Material Testing Without Derivatization 

This application note demonstrates how molecular rotational resonance (MRR) spectroscopy enables direct determination of absolute configuration (AC) and enantiomeric excess (EE) without chromatography, derivatization, or enantiopure reference standards. Using alaninol, a chiral building block used in the synthesis of Cabotegravir, as an example, MRR provides a streamlined workflow for chirality confirmation and impurity analysis in pharmaceutical raw materials.

Application Note Highlights

• Learn how chiral tagging and rotational spectroscopy enable direct chirality determination.

• Explore flexible workflows for both library compounds and new chiral analytes.

• See how MRR differentiates and quantifies alaninol enantiomers using chiral-tagged rotational spectra.

• Understand how MRR supports pharmaceutical quality control through rapid, accurate chirality confirmation.

Download the application note to learn more.