Chiral Analysis of Linalool, an Important Natural Fragrance and Flavor Compound, by Molecular Rotational Resonance Spectroscopy 

Originally Published in symmetry, April 2022
Authors: Reilly E. Sontrom; David M. Cannon; Justin L. Neill

Publication Summary

Originally published in symmetry, this publication explores the use of chiral tagging molecular rotational resonance (MRR) spectroscopy for the analysis of linalool, a naturally occurring terpene that plays an important role in the flavor, fragrance, and aromatherapy properties of many botanical products. Because the sensory characteristics of linalool can depend on its enantiomeric composition, accurate chiral analysis is important for product authentication and quality assessment.

The study demonstrates how chiral tagging MRR spectroscopy can be used to determine the absolute configuration and enantiomeric excess of linalool in complex essential oil mixtures. By forming non-covalent diastereomeric complexes with a chiral tag, the technique can differentiate linalool enantiomers without the need for chromatographic separation or reference standards. The work highlights the potential of MRR as a practical and quantitative tool for routine chiral analysis in flavor, fragrance, and natural products research.