Simplify Chiral Analysis in Drug Development

Confirm absolute configuration and enantiomeric purity—without derivatization or columns.

Read the App Note

What You'll Learn

  • Confirm Chirality Without Chromatography

    How to determine AC and %EE without derivatization, standards, or chiral columns

  • Analyze Difficult Molecules

    Why MRR is ideal for small, reactive compounds like amino alcohols

  • Streamline Chiral Method Development

    How spectraMRR compares to GC on speed and simplicity

Problem and Solution

Problem

Chiral raw materials are essential in drug synthesis—but they're notoriously hard to analyze. Traditional chiral chromatography requires derivatization, expensive enantiopure standards, and often delivers poor resolution for small, polar molecules. These challenges create bottlenecks in pharmaceutical quality control.

Solution

BrightSpec’s isoMRR platform uses gas-phase molecular rotational resonance (MRR) to confirm absolute configuration and enantiomeric excess without chromatography, derivatization, or enantiopure standards. It resolves diastereomeric complexes using chiral tags, delivering accurate, reproducible results for challenging molecules like alaninol.

Hassle-Free Chiral Analysis

Feature MRR Chiral Chromatography
Chiral Columns Not Required Required
Derivatization Not Required Required
Enantiopure Standards Not Required Required
Spectral Overlaps No Often
Analysis Time 15-30 mins 1-2 hours

Rapid Analysis

MRR Analysis Speed

8x

Traditional GC methods

Strong, Clear Signal

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Figure 4 from the app note demonstrates an MRR Signal response and quantitative performance for formaldehyde in aqueous solution.

What Our Customers Are Saying

Testimonial Image 1

Implementing BrightSpec's MRR technology transformed our residual solvent analysis process. We've achieved faster turnaround times and improved accuracy, even with challenging solvent mixtures.

John Doe

CEO, Example Company

Testimonial Image 2

This is the second testimonial. I highly recommend it!

Jane Smith

Marketing Manager, Another Company

MRR in Action

Resources

App Note

Residual Solvent Analysis

Discover residual solvent analysis made simple with MRR.

Learn More

Webinar

MRR in the Classroom and Lab

Two scientists share their experience using MRR instruments for both teaching and research.

Learn More

Brochure

Meet the isoMRR

Streamlined analysis, precise quantification, and chiral clarity—all in one powerful platform.

Learn More

App Note

Residual Solvent Analysis

Discover residual solvent analysis made simple with MRR.

Learn More

Webinar

MRR in the Classroom and Lab

Two scientists share their experience using MRR instruments for both teaching and research.

Learn More

Brochure

Meet the isoMRR

Streamlined analysis, precise quantification, and chiral clarity—all in one powerful platform.

Learn More