Chiral Analysis for Drug Development

Molecule floating above a plate

What You'll Learn from the Application Note

Confirm Chirality Without Chromatography

How to determine AC and %EE without derivatization, standards, or chiral columns
Analyze Difficult Molecules

Why MRR is ideal for small, reactive compounds like amino alcohols
Streamline Chiral Method Development

How spectraMRR compares to GC on speed and simplicity

Solve Chiral Analysis Challenges in Drug Development with MRR

Challenge

Chiral raw materials are essential in drug synthesis—but they're notoriously hard to analyze. Traditional chiral chromatography requires derivatization, expensive enantiopure standards, and often delivers poor resolution for small, polar molecules. These challenges create bottlenecks in pharmaceutical quality control.

Solution

BrightSpec’s isoMRR platform uses gas-phase molecular rotational resonance (MRR) to confirm absolute configuration and enantiomeric excess without chromatography, derivatization, or enantiopure standards. It resolves diastereomeric complexes using chiral tags, delivering accurate, reproducible results for challenging molecules like alaninol.

Hassle-Free Chiral Analysis

Feature	MRR	Chiral Chromatography
Chiral Columns	Not Required	Required
Derivatization	Not Required	Required
Enantiopure Standards	Not Required	Required
Spectral Overlaps	No	Often
Analysis Time	15-30 mins	1-2 hours

What Our Customers Are Saying

Testimonial Image 1

Implementing BrightSpec's MRR technology transformed our residual solvent analysis process. We've achieved faster turnaround times and improved accuracy, even with challenging solvent mixtures.

John Doe

CEO, Example Company

Testimonial Image 2

This is the second testimonial. I highly recommend it!

Jane Smith

Marketing Manager, Another Company